National Highways is advising drivers that the A38 Marsh Mills eastbound entry slip road will be closed this weekend for essential maintenance work.
During the closure, from 8pm on Friday 10 September to 6am on Monday 13 September, traffic will be diverted via Manadon or Plympton/Deep Lane junction to join the A38 eastbound carriageway.
While work to maintain bridge joints takes place, the A38 through Plymouth will be unaffected.
A spokesperson for National Highways said: "We are working closely with our colleagues in Plymouth City Council and apologise for any inconvenience."
Drivers are reminded to allow extra time for their journeys, and regular updates will be issued on the National Highways Twitter feed @HighwaysSWEST.
If you would like further information about this work, please contact National Highways Customer Contact Centre on 0300 123 5000 open 24/7 or email: firstname.lastname@example.org